George C. Prendergast, PhD, LIMR President and CEO
Dr. George Prendergast was appointed president and CEO of the Lankenau Institute for Medical Research (LIMR) in 2004. He is a graduate of the University of Pennsylvania where he was graduated magna cum laude with a Bachelor of Arts with Distinction in Biochemistry in 1983. He obtained his Master of Science in Molecular Biophysics and Biochemistry from Yale University in 1984 and his PhD in Molecular Biology from Princeton University in 1989. Dr. Prendergast is professor, Department of Pathology, Anatomy and Cell Biology, Jefferson Medical College, and co-leader, Cancer Cell Biology and Signaling Program, Kimmel Cancer Center at Thomas Jefferson University in Philadelphia.
With experience in the pharmaceutical industry as well as in academia, Dr. Prendergast is an accomplished cancer researcher recognized for his expertise in cancer biology, signal transduction, and molecular therapeutics. An emergent theme in Dr. Prendergast’s work has been the development of new therapeutics based on modifier genes that strongly affect disease susceptibility and therapeutic response. In his career he has become known as an innovator who has the ability to translate basic research findings toward clinical application, most recently in developing IDO inhibitors as a novel class of drugs to dramatically improve the immune response and therapeutic outcome in cancers treated with chemotherapy, radiotherapy or immunotherapy.
Dr. Prendergast has contributed over 180 publications in the field of cancer research, and he is an inventor or co-inventor on 50 published or pending patents.
Susan Gilmour, PhD, LIMR Deputy Director
Dr. Susan Gilmour has been a professor at LIMR since 1990 and assumed the role of Deputy Director in July 2018. She earned a bachelor’s degree in biology at the University of Virginia where she was also a member of the first women’s varsity crew team. Her PhD in toxicology and pharmacology was awarded from Rutgers University/University of Medicine and Dentistry, followed by a postdoctoral fellowship in molecular carcinogenesis at The Wistar Institute in Philadelphia.
In addition to her roles at LIMR, she is a member of the Sidney Kimmel Cancer Center at Thomas Jefferson University and is an adjunct professor of pathology at Drexel University.
For more than 26 years, Dr. Gilmour’s research has been supported by funding from the National Institutes of Health (NIH). She has served on numerous study sections to review grants for both the NIH and the U.S. Department of Defense. In her lab, she is defining mechanisms by which tumor modifiers, such as polyamines and thrombin, support and accelerate the development of cancer to a malignant, metastatic state. She is also investigating how polyamines recruit mutant stem cell populations to promote the early development of tumors. She is translating her basic research findings to novel polyamine- and thrombin-targeted therapies that may contribute to increased survival in cancer patients.
Robert Cox, PhD, Director, LIMR Scientific Administration
Dr. Cox is LIMR’s director of scientific administration and a LIMR professor since 2000. He earned his Bachelor of Science in Electrical Engineering and his Master of Science in Biomedical Engineering from Drexel University in Philadelphia. He is a graduate of the University of Pennsylvania where he was awarded his PhD in Biomedical Engineering.
Dr. Cox focuses his research on how ion channels regulate blood pressure and the electrical signals that drive heartbeat, specifically a type of calcium channel that is present only in arteries. Calcium channels are microscopic molecular machines that regulate the flow of calcium across cellular membranes. By targeting the special type of calcium channel found exclusively in blood vessels, not found in heart muscle, Dr. Cox's research will lead to the development of more effective, safe and selective therapy against high blood pressure.
Board of trustees
- Peter H. Havens, Board Chairman
Chairman & Portfolio Manager, Baldwin Management, LLC
- George C. Prendergast, PhD, President
- John Wellenbach, Secretary
- David Berkowitz, FACHE
- Joseph Bushra, MD
- Alice Chase, RN
- Jonathan Charles Fox, MD, PhD
- Paul B. Gilman, MD
- Karen Gotting-Smith, PhD
- Peter R. Kowey, MD
- I. Wistar Morris, III, MBA, CFA
- Amber Salzman, PhD
- Sara Senior
- Elizabeth Balderston
- Joseph Gobern, MD
- Lawrence Livornese, MD
- John J. Lynch III, FACHE
- George Prendergast, PhD
- Alfred W. Putnam, Jr., Esq.
- Phillip D. Robinson, FACHE
- Patrick Ross, MD