Lead investigator: Alexander J. Muller, PhD
Diabetic retinopathy (DR) and the “wet” form of age-related macular degeneration (AMD) are increasing in incidence worldwide. These retinopathies are caused by the pathogenic growth of blood vessels (angiogenesis) on the surface of the retina, obscuring vision. Present treatments are laser therapy or injectable drugs that block VEGF, which stimulates formation of new blood vessels. However, these treatments are not fully effective. For example, up to 30% of patients receiving anti-VEGF are non-responders, and long-term treatment actually may be deleterious in treating DR. Thus, there remains a need for drugs or biologics to safely and effectively treat these common retinopathies.
The global number of cases of AMD are expected to grow from 196 million in 2020 to 288 million in 2040 (Wong, et al; see reference). About 4.2 million U.S. adults have DR, and 655,000 have vision-threatening DR, according to the CDC.
For companies developing IDO/TDO inhibitors in clinical trials, this technology could expand the scope of marketable applications for this drug class to encompass the field of ophthalmology.
As part of their pioneering studies of IDO enzymes as targets for immunotherapeutic development, LIMR scientists discovered that the IDO1 enzyme also contributes significantly to inflammatory vasculogenesis. Exploring this direction, they defined a new use for IDO inhibitors to treat retinopathies that are driven by formation of pathogenic blood vessels. This new use expands clinical applications for IDO inhibitors as potential medicines in ophthalmology.
This new use of IDO inhibitors could expand their clinical applications as medicines in ophthalmology.
Stage of development
Preclinical proof of concept for repositioning this drug class has been achieved, including with two clinical stage IDO inhibitors.
New use for IDO1 inhibitors (daily oral monotherapy): Patent pending.
Efficacy evaluation of IDO inhibitors alone or in combination with anti-VEGF, laser, or other modalities used to treat retinopathy, to improve management of DR, AMD, retinopathy of prematurity.
- Mondal A, Smith C, DuHadaway JB, Sutanto-Ward E, Prendergast GC, Bravo-Nuevo A and Muller AJ (2016) IDO1 is an integral mediator of inflammatory neovascularization. EBioMedicine 14:74-82.
- Mondal A, Dey S, DuHadaway JB, Sutanto-Ward E, Laury-Kleintop L, Thomas S, Prendergast GC, Mandik-Nayak L and Muller AJ. IDO1 acts in a unique subpopulation of Gr1+ CD11blo immune cells to support inflammatory neovascularization. (Manuscript in revision.)
- Wong WL, Su X, Li X, et al. (2014) Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis. Lancet Glob Health Feb;2(2):e106-16.
Institutional contact: George C. Prendergast, PhD, LIMR President and CEO, 484.476.8475, email@example.com
IP manager contact: Heather Rose, PhD, JD, VP of Technology Licensing and Startups, Thomas Jefferson University, 215.503.0770, firstname.lastname@example.org