The following books authored by LIMR researchers have been published in recent years:


Cardiac Arrhythmias, Pacing and Sudden Death (Cardiovascular Medicine)

Peter Kowey, MD, LIMR professor and world-renowned cardiologist at Lankenau Heart Institute in Lankenau Medical Center, co-authored the textbook “Cardiac Arrhythmias, Pacing and Sudden Death” (Springer, 2017), which provides up-to-date, user-friendly and comprehensive guidance on the evaluation, diagnosis, and medical and surgical treatment of cardiac arrhythmias. The book aids every trainee and practicing cardiologist, cardiac electrophysiologist, cardiac surgeon, vascular surgeon, and physician who manages cardiac patients.

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Sunil Thomas, PhD, a research assistant professor who specializes in immunology at the LIMR, wrote “Rickettsiales: Biology, Molecular Biology, Epidemiology, and Vaccine Development” (Springer, 2017), the first comprehensive book that covers every genera of the order Rickettsiales, small proteobacteria that are known to cause diseases in humans and animals.

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Preserving the Promise: Improving the Culture of Biotech Investment

For anyone who has ever wondered why—with so much focus and funds flowing into the biotechnology arena — there are relatively few extraordinary breakthroughs realized, a book co-authored by LIMR’s Scott Dessain, MD, PhD, can shed light on the challenges. In their book “Preserving the Promise: Improving the Culture of Biotech Investment” (Academic Press, 2016), the authors also point the way to strategies that, if adopted, could improve the chances of more life-saving (and affordable) therapies transitioning from the laboratory to the clinic.

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J Wave Syndromes: Brugada and Early Repolarization Syndromes

“(Springer, 2016) Edited by LIMR Professors Charles Antzelevitch and Gan-Xin Yan delineates the state of the art of the diagnosis and treatment of J wave syndromes, as well as where future research needs should be directed. It covers basic science, translational and clinical aspects of these syndromes. The authors are leading experts in their respective fields, who have contributed prominently to the literature concerning these topics.

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Vaccine Design - Methods and Protocols: Volume 1: Vaccines for Human Diseases

This text provides a practical step-by-step protocol to design and develop vaccines. Chapters detail protocols for developing novel vaccines against infectious bacteria, viruses, fungi, and parasites for humans and animals. “Vaccines for Human Diseases, Vol. 1” (Humana Press, 2016) has an introductory section on how vaccines impacted diseases, the immunological mechanism of vaccines, future challenges for vaccinologists, and current trends in vaccinology. The design of human vaccines for viral, bacterial, fungal, parasitic and prion diseases, as well as vaccines for drug abuse, allergy, and tumor vaccines, are also described in this volume.

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Vaccine Design - Methods and Protocols, Volume 2: Vaccines for Veterinary Diseases

This text provides step-by-step protocol to design and develop vaccines. Chapters detail protocols for developing novel vaccines against infectious bacteria, viruses, fungi, and parasites. “Vaccines for Veterinary Diseases, Vol. 2” (Humana Press, 2016) includes vaccines for farm animals and fishes, vaccine vectors and production, vaccine delivery systems, vaccine bioinformatics, vaccine regulation and intellectual property.

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Cancer Immunotherapy: Immune Suppression and Tumor Growth, 2nd Ed.

This book, co-edited by LIMR President and CEO George Prendergast, PhD, highlights emerging new principles of immune suppression that drive cancer, and it offers new ideas about how therapy can be improved by attacking these principles (Academic Press, 2013).

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Journal publications

Yoon N, Patocskai B, Antzelevitch C. Epicardial Substrate as a Target for Radiofrequency Ablation in an Experimental Model of Early Repolarization Syndrome. Circ Arrhythm Electrophysiol. 2018 Sep;11(9).

Sicouri S, Belardinelli L, Antzelevitch C. Effect of autonomic influences to induce triggered activity in muscular sleeves extending into the coronary sinus of the canine heart and its suppression by ranolazine. J Cardiovasc Electrophysiol. 2018 Oct 9.

Nevler A, Muller AJ, Sutanto-Ward E, DuHadaway JB, Nagatomo K, … Mandik-Nayak L, Winter JM, Yeo CJ, Prendergast GC, Brody JR. Host IDO2 gene status influences tumor progression and radiotherapy response in KRAS-driven sporadic pancreatic cancers. Clin Cancer Res. 2018 Sep 28.

Thomas S, … Prendergast GC, Mullin JM. Intestinal barrier tightening by a cell-penetrating antibody to Bin1, a candidate target for immunotherapy of ulcerative colitis. J Cell Biochem. 2018 Sep 30.

Fox E, Oliver T, Rowe M, Thomas S, Zakharia Y, Gilman PB, Muller AJ, Prendergast GC. Indoximod: An Immunometabolic Adjuvant That Empowers T Cell Activity in Cancer. Front Oncol. 2018 Sep 11;8:370.

Thind M, Holmes DN, Badri M, Kowey PR, … et al. Embolic and Other Adverse Outcomes in Symptomatic Versus Asymptomatic Patients With Atrial Fibrillation (from the ORBIT-AF Registry). Am J Cardiol. 2018 Aug 20.

Muller AJ, Manfredi MG, Zakharia Y, Prendergast GC. Inhibiting IDO pathways to treat cancer: lessons from the ECHO-301 trial and beyond. Semin Immunopathol. 2018 Sep 10.

Castro Hevia J, Dorantes Sanchez M, … Antzelevitch C, et. al. Multiple serial ECGs aid with the diagnosis and prognosis of Brugada syndrome. Int J Cardiol. 2018 Aug 30.

Burashnikov A, Antzelevitch C. Is extensive atrial fibrosis in the setting of heart failure associated with a reduced atrial fibrillation burden? Pacing Clin Electrophysiol. 2018 Aug 27.

Qi D, Gao Y, Yan GX. Electrocardiographic J wave: Early repolarization, Brugada wave, and conduction delay. Heart Rhythm. 2018 Aug 14.

McTigue KM, Hartelius EJ, Anderson TS, … Larson SL, et al. Using a deliberative forum for engaging health system and health plan leaders to prioritize research topics. 2018; 6(2).

Sharma R, Al-Saleem FH, Panzer J, ... Cox RH, Dessain SK. Monoclonal antibodies from a patient with anti-NMDA receptor encephalitis. Annals of Clinical and Translational Neurology. 2018 Jul 5.

Sharma R, Al-Saleem FH, Puligedda RD, Rattelle A, Lynch DR, Dessain SK. Membrane-bound and soluble forms of an NMDA receptor extracellular domain retain epitopes targeted in auto-immune encephalitis. BMC Biotechnol. 2018 Jun 27;18(1):41.

Camm JA, Dorian P, Hohnloser SH, Kowey PR, et al. A randomized, double-blind, placebo-controlled trial assessing the efficacy of S66913 in patients with paroxysmal atrial fibrillation. Eur Heart J Cardiovasc Pharmacother. 2018 Jul 23;11(14):1401-10.

Jackson LR 2nd, Kim S, Shrader P, Blanco R, Thomas L, Ezekowitz MD, Ansell J, Fonarow GC, Gersh BJ, Go AS, Kowey PR, et al. Early therapeutic persistence on dabigatran versus warfarin therapy in patients with atrial fibrillation: results from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) registry. J Thromb Thrombolysis. 2018 Jul 26, pp1-5.

Argenziano M, Antzelevitch C. Recent advances in the treatment of Brugada syndrome. Expert Rev Cardiovasc Ther. 2018 Jun;16(6):387-404.

Turner JR, Rodriguez I, Mantovani E, Gintant G, Kowey PR, et al. Drug‐induced Proarrhythmia and Torsade de Pointes: A Primer for Students and Practitioners of Medicine and Pharmacy. J Clin Pharmacol 2018 April 19.

Kowey PR, Fudim M, Liu PR, Shrader P, et al. Mineralocorticoid Receptor Antagonism in Patients With Atrial Fibrillation: Findings From the ORBIT-AF Registry. J Am Heart Assoc. Apr 13, 2018;7(8).

Yan GX, Tse G, Wong CW, et al. Meta-analysis of T-wave indices for risk stratification in myocardial infarction. International Health Informatics Study (IHIS) Network. J Geriatr Cardiol. 2017 Dec;14(12):776-779.

Prendergast GC, Mondal A, Dey S, Laury-Kleintop LD, Muller AJ. Inflammatory Reprogramming with IDO1 Inhibitors: Turning Immunologically Unresponsive 'Cold' Tumors 'Hot'. Trends Cancer. 2018 Jan;4(1):38-58.

Nevler A, Muller AJ, Cozzitorto JA, Goetz A, Winter JM, Yeo TP, Lavu H, Yeo CJ, Prendergast GC, Brody JR. A Sub-Type of Familial Pancreatic Cancer: Evidence and Implications of Loss-of-Function Polymorphisms in Indoleamine-2,3-Dioxygenase-2. J Am Coll Surg. 2018 Feb 7.

Peters MC, Minton A, Phanstiel Iv O, Gilmour SK. A Novel Polyamine-Targeted Therapy for BRAF Mutant Melanoma Tumors. Med Sci (Basel). 2018 Jan 5;6(1). pii: E3.

Prendergast GC, Malachowski WJ, Mondal A, Scherle P, Muller AJ. Indoleamine 2,3-Dioxygenase and Its Therapeutic Inhibition in Cancer. Int Rev Cell Mol Biol. 2018;336:175-203.

DiGuilio KM, Valenzano MC, Rybakovsky E, Mullin JM. Cobalt chloride compromises transepithelial barrier properties of CaCo-2 BBe human gastrointestinal epithelial cell layers. BMC Gastroenterol. 2018 Jan 5;18(1):2.

Thomas KL, Jackson LR 2nd, Shrader P, Ansell J, Fonarow GC, Gersh B, Kowey PR, et al. Prevalence, Characteristics, and Outcomes of Valvular Heart Disease in Patients With Atrial Fibrillation: Insights From the ORBIT-AF. J Am Heart Assoc. 2017 Dec 22;6(12). pii: e006475.

Conti S, Reiffel JA, Gersh BJ, Kowey PR, et al. Baseline Demographics, Safety, and Patient Acceptance of an Insertable Cardiac Monitor for Atrial Fibrillation Screening: The REVEAL-AF Study. J Atr Fibrillation. 2017 Feb 28;9(5):1551.

Prendergast GC, Malachowski WP, DuHadaway JB, Muller AJ. Discovery of IDO1 Inhibitors: From Bench to Bedside. Cancer Res. 2017 Dec 15;77(24):6795-6811.

Rybakovsky E, Valenzano MC, Deis R, DiGuilio KM, Thomas S, Mullin JM. Improvement of Human-Oral-Epithelial-Barrier Function and of Tight Junctions by Micronutrients. J Agric Food Chem. 2017 Dec 20;65(50):10950-10958.