The following books authored by LIMR researchers have been published in recent years:
Cardiac Arrhythmias, Pacing and Sudden Death (Cardiovascular Medicine)
Peter Kowey, MD, LIMR professor and world-renowned cardiologist at Lankenau Heart Institute in Lankenau Medical Center, co-authored the textbook “Cardiac Arrhythmias, Pacing and Sudden Death” (Springer, 2017), which provides up-to-date, user-friendly and comprehensive guidance on the evaluation, diagnosis, and medical and surgical treatment of cardiac arrhythmias. The book aids every trainee and practicing cardiologist, cardiac electrophysiologist, cardiac surgeon, vascular surgeon, and physician who manages cardiac patients.
Sunil Thomas, PhD, a research assistant professor who specializes in immunology at the LIMR, wrote “Rickettsiales: Biology, Molecular Biology, Epidemiology, and Vaccine Development” (Springer, 2017), the first comprehensive book that covers every genera of the order Rickettsiales, small proteobacteria that are known to cause diseases in humans and animals.
Preserving the Promise: Improving the Culture of Biotech Investment
For anyone who has ever wondered why — with so much focus and funds flowing into the biotechnology arena — there are relatively few extraordinary breakthroughs realized, a book co-authored by LIMR’s Scott Dessain, MD, PhD, can shed light on the challenges. In their book “Preserving the Promise: Improving the Culture of Biotech Investment” (Academic Press, 2016), the authors also point the way to strategies that, if adopted, could improve the chances of more life-saving (and affordable) therapies transitioning from the laboratory to the clinic.
J Wave Syndromes: Brugada and Early Repolarization Syndromes
“(Springer, 2016) Edited by LIMR Professors Charles Antzelevitch and Gan-Xin Yan delineates the state of the art of the diagnosis and treatment of J wave syndromes, as well as where future research needs should be directed. It covers basic science, translational and clinical aspects of these syndromes. The authors are leading experts in their respective fields, who have contributed prominently to the literature concerning these topics.
Vaccine Design - Methods and Protocols: Volume 1: Vaccines for Human Diseases
This text provides a practical step-by-step protocol to design and develop vaccines. Chapters detail protocols for developing novel vaccines against infectious bacteria, viruses, fungi, and parasites for humans and animals. “Vaccines for Human Diseases, Vol. 1” (Humana Press, 2016) has an introductory section on how vaccines impacted diseases, the immunological mechanism of vaccines, future challenges for vaccinologists, and current trends in vaccinology. The design of human vaccines for viral, bacterial, fungal, parasitic and prion diseases, as well as vaccines for drug abuse, allergy, and tumor vaccines, are also described in this volume.
Vaccine Design - Methods and Protocols, Volume 2: Vaccines for Veterinary Diseases
This text provides step-by-step protocol to design and develop vaccines. Chapters detail protocols for developing novel vaccines against infectious bacteria, viruses, fungi, and parasites. “Vaccines for Veterinary Diseases, Vol. 2” (Humana Press, 2016) includes vaccines for farm animals and fishes, vaccine vectors and production, vaccine delivery systems, vaccine bioinformatics, vaccine regulation and intellectual property.
Cancer Immunotherapy: Immune Suppression and Tumor Growth, 2nd Ed.
This book, co-edited by LIMR President and CEO George Prendergast, PhD, highlights emerging new principles of immune suppression that drive cancer, and it offers new ideas about how therapy can be improved by attacking these principles (Academic Press, 2013).
Kowey PR, Fudim M, Liu PR, Shrader P, et al. Mineralocorticoid Receptor Antagonism in Patients With Atrial Fibrillation: Findings From the ORBIT-AF Registry. J Am Heart Assoc. Apr 13, 2018;7(8).
Yan GX, Tse G, Wong CW, et al. Meta-analysis of T-wave indices for risk stratification in myocardial infarction. International Health Informatics Study (IHIS) Network. J Geriatr Cardiol. 2017 Dec;14(12):776-779.
Prendergast GC, Mondal A, Dey S, Laury-Kleintop LD, Muller AJ. Inflammatory Reprogramming with IDO1 Inhibitors: Turning Immunologically Unresponsive 'Cold' Tumors 'Hot'. Trends Cancer. 2018 Jan;4(1):38-58.
Nevler A, Muller AJ, Cozzitorto JA, Goetz A, Winter JM, Yeo TP, Lavu H, Yeo CJ, Prendergast GC, Brody JR. A Sub-Type of Familial Pancreatic Cancer: Evidence and Implications of Loss-of-Function Polymorphisms in Indoleamine-2,3-Dioxygenase-2. J Am Coll Surg. 2018 Feb 7. doi.org/10.1016/j.jamcollsurg.2017.12.052.
Peters MC, Minton A, Phanstiel Iv O, Gilmour SK. A Novel Polyamine-Targeted Therapy for BRAF Mutant Melanoma Tumors. Med Sci (Basel). 2018 Jan 5;6(1). pii: E3.
Prendergast GC, Malachowski WJ, Mondal A, Scherle P, Muller AJ. Indoleamine 2,3-Dioxygenase and Its Therapeutic Inhibition in Cancer. Int Rev Cell Mol Biol. 2018;336:175-203.
DiGuilio KM, Valenzano MC, Rybakovsky E, Mullin JM. Cobalt chloride compromises transepithelial barrier properties of CaCo-2 BBe human gastrointestinal epithelial cell layers. BMC Gastroenterol. 2018 Jan 5;18(1):2.
Thomas KL, Jackson LR 2nd, Shrader P, Ansell J, Fonarow GC, Gersh B, Kowey PR, et al. Prevalence, Characteristics, and Outcomes of Valvular Heart Disease in Patients With Atrial Fibrillation: Insights From the ORBIT-AF. J Am Heart Assoc. 2017 Dec 22;6(12). pii: e006475.
Conti S, Reiffel JA, Gersh BJ, Kowey PR, et al. Baseline Demographics, Safety, and Patient Acceptance of an Insertable Cardiac Monitor for Atrial Fibrillation Screening: The REVEAL-AF Study. J Atr Fibrillation. 2017 Feb 28;9(5):1551.
Prendergast GC, Malachowski WP, DuHadaway JB, Muller AJ. Discovery of IDO1 Inhibitors: From Bench to Bedside. Cancer Res. 2017 Dec 15;77(24):6795-6811.
Rybakovsky E, Valenzano MC, Deis R, DiGuilio KM, Thomas S, Mullin JM. Improvement of Human-Oral-Epithelial-Barrier Function and of Tight Junctions by Micronutrients. J Agric Food Chem. 2017 Dec 20;65(50):10950-10958.
Alexander ET, Minton A, Peters MC, Phanstiel O 4th, Gilmour SK. A novel polyamine blockade therapy activates an anti-tumor immune response. Oncotarget. 2017 Aug 24;8(48):84140-84152.
Laury-Kleintop L, Pestell TG, Jiao X, et al. Stromal cyclin D1 promotes heterotypic immune signaling and breast cancer growth. Oncotarget. 2017 Aug 4;8(47):81754-81775.
Peng W, Furuuchi N, Aslanukova L, Huang YH, Sawicki JA, et al. Elevated HuR in Pancreas Promotes a Pancreatitis-like Inflammatory Microenvironment that Facilitates Tumor Development. Mol Cell Biol. 2017 Nov 13.
Antzelevitch C, Patocskai B. Ajmaline-Induced Slowing of Conduction in the Right Ventricular Outflow Tract Cannot Account for ST Elevation in Patients With Type I Brugada ECG.Circ Arrhythm Electrophysiol. 2017 Oct;10(10).