Observational study of COVID-19 patients

Study ID: ECMOCARD

Extracorporeal membrane oxygenation for 2019 novel coronavirus acute respiratory disease

ECMOCARD is a multicenter observational study of patients who have been diagnosed with COVID-19 and are being treated in hospitals and intensive care units (ICU) that are participating in this research, which includes Main Line Health. The study aims to describe clinical features of patients with COVID-19.

Patients are studied from the time of ICU admission until hospital discharge or up to 28 days after ICU admission, whichever occurs later. Clinical data will be recorded only if it is taken as part of routine clinical practice. Only de-identified data is submitted to the study’s central investigators.

This is an international, multicenter, prospective/retrospective observational study of COVID-19 patients in participating hospitals and ICUs.

All patients admitted to the ICU with lab-confirmed COVID-19 infection with real-time PCR and/or next-generation sequencing will be included in this study, which seeks to characterize the following features:

  • incidence of ICU admission, use of mechanical ventilation and ECMO
  • risk factors
  • clinical features
  • coagulation disorders and thrombosis
  • severity of respiratory failure
  • need for non-invasive and invasive mechanical ventilation and ECMO
  • settings of invasive mechanical ventilation
  • ECMO technical characteristics and duration
  • complications
  • ICU and hospital survival
  • requirements and time frame for approvals in each participating network region for this study

Inclusion Snapshot

  • Must have been admitted to an ICU with lab-confirmed COVID-19 infection
  • Patients receiving mechanical ventilation or ECMO for other concomitant causes will be excluded

Contact Information

Lankenau Institute for Medical Research trial