David O. Holtz, MD

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Practice Philosophy

Main Line Gynecologic Oncology physicians provide complete and compassionate care for women and their families facing cancer or precancerous conditions of the ovaries, uterus, cervix, vulva or vagina. Our team of doctors, physician assistants and nurses help guide you through the complex process of evaluation, management, surgery and chemotherapy treatment of gynecologic cancers. We provide cutting-edge surgical chemotherapy care and participation in clinical trials which are individualized for each patient to get superior results. In addition, we possess clinical expertise in preventive oncology, helping women who are at high risk for gynecologic cancers, and in the surgical management of complex benign gynecologic conditions including fibroids, ovarian masses and cysts. We see new oncology patients within 48 hours.

Practice Name
  • Main Line Gynecologic Oncology
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This doctor is employed by Main Line HealthCare, the multispecialty physician network of Main Line Health, including more than 350 community and hospital-based physicians.

Locations and Appointments

Lankenau MOB East, Suite 661
100 East Lancaster Avenue
Wynnewood, PA 19096

Do you have questions or are you looking for help in choosing the right provider?

Call 1.866.CALL.MLH (1.866.225.5654), Monday through Friday between 8:00 am–6:00 pm ET, to speak with a member of our referral staff who can help find the doctor who is right for you.

About David O. Holtz, MD

I hope to form a partnership with a patient and her family and to educate them about their disease and treatment options. Our practice sees patient in a very stressful time: they may be facing a new diagnosis of cancer, the possibility of surgery, or the start of chemotherapy. My office and I want to help you in this journey.

Dr. Holtz is the Division Chief of Gynecologic Oncology with Main Line Health Care Gynecologic Oncology with offices in Wynnewood and Paoli Pennsylvania. He is the first gynecologic surgeon in Pennsylvania to perform procedures for uterine and cervical cancer with the daVinci Robot, and he is a Clinical Assistant Professor with Thomas Jefferson University Hospital and the Lankenau Institute for Medical Research. Dr. Holtz’s clinical interests include minimally invasive surgery for women’s cancers.

  • Gender: Male
  • Years of Experience: 13
  • Language: English
Specialties Accepting New Patients
Gynecologic Oncology Board certified since 2008
Primary Affiliation
Primary Treatments
Clinical Titles
  • Main Line Health System Division Chief - Gynecologic Oncology


Medical school
  • Jefferson Medical College
  • Jefferson Medical College
  • Thomas Jefferson University Hospital
  • Thomas Jefferson University Hospital
  • Thomas Jefferson University Hospital
  • Thomas Jefferson University Hospital
  • Hospital of the University of Pennsylvania
  • Hospital of the University of Pennsylvania

*Members of the Main Line Health medical staff are affiliated with Bryn Mawr Hospital, Lankenau Medical Center, Paoli Hospital and Riddle Hospital. Membership on the medical staff of any of our hospitals does not constitute an employment or agency relationship.

Awards & Memberships

Current Membership & Activities
  • American Association of Gynecologic Laparoscopists
  • American Society for Colposcopy and Cervical Pathology
  • Society of Gynecologic Oncologists
  • Mid-Atlantic Gynecologic Oncology Society
  • American College of Obstetrics & Gynecology
  • Pennsylvania Medical Society