PAD blocks blood flow to the legs and feet, causing significant pain and limited mobility, potentially leading to surgery or even amputation in severe cases. Caused by the buildup of plaque and calcium within the walls of arteries, PAD occurs primarily in the legs, but can be found in vessels throughout the body. Balloon angioplasty, which involves inflating a balloon within the artery at the area of narrowing and expanding the artery to alleviate the blockage, is commonly used to treat PAD. Many patients do not respond well to angioplasty alone, with failure rates as high as 50 percent often due to hardened calcium within the wall of the artery.
“This is yet another example of the Lankenau Heart Institute’s commitment to providing cutting-edge treatment options for patients with heart and vascular conditions,” said Sarang Mangalmurti, MD, an interventional cardiologist at Bryn Mawr Hospital. “We’re thrilled to be the first in the region to offer this technology, which gives us the ability to more effectively treat hardened calcium with potentially less risk of damage or injury to the vessel.”
Shockwave Medical’s Lithoplasty system integrates angioplasty balloon catheter devices with the calcium-disrupting power of sonic pressure waves, known as lithotripsy. Each Lithoplasty catheter incorporates multiple lithotripsy emitters activated with the touch of a button after the balloon is inflated. Once activated, these emitters produce therapeutic sonic pressure waves that are inherently tissue-selective, passing through the balloon and soft vascular tissue, without damage and preferentially disrupting the calcified plaque inside the vessel wall by creating a series of micro-fractures. When the calcium has been modified, the vessel can be dilated using low pressures, thereby enabling even historically challenging PAD patients to be treated effectively with minimal injury to the vessel.
The technology is now commercially available in both the United States and Europe for the treatment of calcified plaque in peripheral arteries. On behalf of Lankenau Heart Institute, Bryn Mawr Hospital is serving as a clinical test site for Lithoplasty and will continue to participate in trials evaluating best practice usage and the effectiveness of this technology. William Gray, MD, system chief of the division of cardiovascular disease at Main Line Health and president of the Lankenau Heart Institute, is leading this important trial as its national principle investigator.
The Shockwave Medical Lithoplasty system is intended for lithotripsy-enhanced balloon dilatation of lesions, including calcified lesions, in the peripheral vasculature, including the iliac, femoral, ilio-femoral, popliteal, infra-popliteal, and renal arteries. Not for use in the coronary or cerebral vasculature.
Founded in 1985, Main Line Health (MLH) is a not-for-profit health system serving portions of Philadelphia and its western suburbs. At its core are four of the region’s respected acute care hospitals—Lankenau Medical Center, Bryn Mawr Hospital, Paoli Hospital and Riddle Hospital—as well as one of the nation’s premier facilities for rehabilitative medicine, Bryn Mawr Rehabilitation Hospital; Mirmont Treatment Center for drug and alcohol recovery; and Main Line Health HomeCare & Hospice, a home health service. Main Line Health also consists of Main Line HealthCare, one of the region’s largest multi-specialty physician networks, and the Lankenau Institute for Medical Research, a non-profit biomedical research organization located on the campus of Lankenau Medical Center. Main Line Health is also comprised of five outpatient health centers.
With more than 10,000 employees and 2,000 physicians, Main Line Health is the recipient of numerous awards for quality care and service, including System Magnet® designation, the nation’s highest distinction for nursing excellence, and recognition as among the nation’s best employers by Forbes magazine. Main Line Health is committed to creating an environment of diversity, respect and inclusion and has proudly embraced the American Hospital Association’s #123forEquity Pledge to Act to eliminate disparities in care. We are dedicated to advancing patient-centered care, education and research to help our community stay healthy.
About Bryn Mawr Hospital
Bryn Mawr Hospital, a member of Main Line Health, is a 319-bed, not-for-profit acute-care teaching hospital dedicated to helping the community stay well ahead on the path to lifelong health. Bryn Mawr Hospital has been named as one of the top six hospitals in the Philadelphia metro area and top 12 in the state of Pennsylvania by U.S. News & World Report’s Best Hospitals 2016–2017, and is ranked as high-performing in the specialties of orthopedics and urology. U.S. News & World Report also ranked Bryn Mawr Hospital as high performing in the following Common Core specialty areas: abdominal aortic aneurysm repair, COPD, colon cancer surgery, congestive heart failure, hip replacement, knee replacement and lung cancer surgery. Bryn Mawr Hospital has earned Magnet® designation for the third time for its superior nursing staff. Bryn Mawr Hospital’s Neuro-Cardiac Intensive Care Unit (NCICU) has also received the 2015–2018 American Association of Critical-Care Nurses (AACN) Silver-level Beacon Award for Excellence for the second time. The National Institutes of Health Commission on Cancer has accredited our Cancer Center and our Comprehensive Breast Center has been accredited by the Joint Commission and the National Accreditation Program for Breast Centers. Bryn Mawr Hospital’s Bariatric Program has earned the MBSAQIP Accredited Comprehensive Center designation from the American Society of Metabolic and Bariatric Surgery. The Hospital offers a full range of services, including cancer care, orthopedic care, cardiovascular care, behavioral health, maternity care, bariatric surgery, neurovascular and a level III neonatal intensive care unit, all aided by a dedicated team of health care professionals and innovative technology such as the Intuitive Surgical System's da Vinci Robot and Navio Robotic Arm Orthopedic System. Through Bryn Mawr Hospital’s collaboration with the Jefferson Hospital for Neuroscience, the university-affiliated Neurovascular Center offers rapid access to advanced diagnostics and treatment options for stroke care. Bryn Mawr Hospital has also collaborated with Nemours/Alfred I. duPont Hospital for Children to include round-the-clock pediatric care for the pediatric inpatient unit and in the pediatric emergency department with additional board-certified, fellowship trained pediatric emergency medicine physicians.