Associate Professor Laura Mandik-Nayak’s research on the enzyme IDO2 and
its role in Rheumatoid arthritis (RA) was selected for the cover of
of Immunology. The publication behind the image, entitled “IDO2
Is a Critical Mediator of Autoantibody Production and Inflammatory
Pathogenesis in a Mouse Model of Autoimmune Arthritis,” provides
support for the theory that IDO2 expression is crucial for the
development of RA.
IDO1 and its variant, IDO2 are called immunomodulatory enzymes. These
types of proteins affect the type or “flavor” of inflammatory response,
allowing disease to take hold in the body. The IDO family has been shown
by another LIMR research group to suppress the immune system during
cancer growth. Altered IDO1 and IDO2 activity has also been associated
with autoimmune disorders such as Rheumatoid arthritis. However, it has
not been made clear how they contribute to the disease and its symptoms.
Dr. Mandik-Nayak’s group examined both IDO1 and IDO2 in relation to
autoimmune arthritis development in the hopes of finding that
connection. Their work reveals that IDO2, but not IDO1, is an important
component of developing arthritic symptoms like inflammation and
autoantibody production. They found that IDO2 drives the autoreactive T
and B cell response leading to arthritis. The enzyme appears to
specifically affect the production of autoantibodies, but does not seem
to play a role in mediating antibody responses in general.
“The results from these studies provide the first direct evidence of a
pathogenic role for IDO2 in driving B cell-mediated autoimmune disease,”
Dr. Mandik-Nayak states. “Together, our data suggest that IDO2 is a
potential new target molecule for the development of new therapies to
treat RA and other autoantibody-mediated autoimmune diseases.”
This work was supported by National Institute of Arthritis and
Musculoskeletal and Skin Diseases/National Institutes of Health Grant
5-R01 AR057847 (to LM-N).
The content of this press release is solely the responsibility
of the authors and does not necessarily represent the official views of
the National Institutes of Health.
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Lankenau Institute for Medical Research (LIMR) is a nonprofit biomedical research institute located on the campus of Lankenau Medical Center and is part of Main Line Health. Founded in 1927, LIMR's mission is to improve human health and well-being. Faculty and staff are devoted to advancing innovative new approaches to formidable medical challenges, including cancer, cardiovascular disease, gastrointestinal disorders and autoimmune diseases, such as diabetes and arthritis. LIMR's principal investigators conduct basic, preclinical and translational research, using their findings to explore ways to improve disease detection, diagnosis, treatment and prevention. They are committed to extending the boundaries of human health through technology transfer and training of the next generation of scientists and physicians.