LIMR Associate Professor Laura Mandik-Nayak’s research on the enzyme IDO2 and its role in Rheumatoid arthritis (RA) was selected for the cover of March’s Journal of Immunology. The publication behind the image, entitled “IDO2 Is a Critical Mediator of Autoantibody Production and Inflammatory Pathogenesis in a Mouse Model of Autoimmune Arthritis,” provides support for the theory that IDO2 expression is crucial for the development of RA.
IDO1 and its variant, IDO2 are called immunomodulatory enzymes. These types of proteins affect the type or “flavor” of inflammatory response, allowing disease to take hold in the body. The IDO family has been shown by another LIMR research group to suppress the immune system during cancer growth. Altered IDO1 and IDO2 activity has also been associated with autoimmune disorders such as Rheumatoid arthritis. However, it has not been made clear how they contribute to the disease and its symptoms.
Dr. Mandik-Nayak’s group examined both IDO1 and IDO2 in relation to autoimmune arthritis development in the hopes of finding that connection. Their work reveals that IDO2, but not IDO1, is an important component of developing arthritic symptoms like inflammation and autoantibody production. They found that IDO2 drives the autoreactive T and B cell response leading to arthritis. The enzyme appears to specifically affect the production of autoantibodies, but does not seem to play a role in mediating antibody responses in general.
“The results from these studies provide the first direct evidence of a pathogenic role for IDO2 in driving B cell-mediated autoimmune disease,” Dr. Mandik-Nayak states. “Together, our data suggest that IDO2 is a potential new target molecule for the development of new therapies to treat RA and other autoantibody-mediated autoimmune diseases.”
This work was supported by National Institute of Arthritis and Musculoskeletal and Skin Diseases/National Institutes of Health Grant 5-R01 AR057847 (to LM-N).
The content of this press release is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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