A Philadelphia couple is the first to have a child born through a new screening technique that identifies which embryos created by in vitro fertilization (IVF) are most likely to lead to successful pregnancies. This new genome sequencing technique, which has never before been applied in the screening of embryos, was used by Michael Glassner, MD, founding director of the Center for Reproductive Medicine at Bryn Mawr Hospital, part of Main Line Health, and medical director of the Main Line Fertility Center (MLFC).
“It’s an honor to be involved in this groundbreaking technology in fertility treatment,” says Dr. Glassner. “Screening embryos will revolutionize the field of infertility and will provide hope for families who are suffering while trying to get pregnant. This technology is going to significantly impact pregnancy rates and I think it will soon become the standard of care.”
The technique is known as “next generation sequencing” (NGS), a powerful method capable of decoding entire genomes. Vast quantities of DNA data are produced from each sample tested, simultaneously revealing information on the inheritance of genetic disorders, chromosome abnormalities and mitochondrial mutations.
As part of the study, the patient’s eggs were retrieved and then fertilized in the MLFC laboratory, and the resulting embryos were biopsied and frozen. The biopsied cells were sent to Dr. Wells’ team, who performed the new method for screening embryos. The embryos were screened for the correct number of chromosomes, and any embryo with a normal number of chromosomes was thawed and implanted into the patient, who delivered a healthy baby boy in May of 2013.
The details of this screening technique were reported at the annual meeting of the European Society of Human Reproduction (ESHRE) in London. Scientists at MLFC in Bryn Mawr, PA co-authored the research findings that were presented at the meeting by Dr. Dagan Wells of the NIHR Biomedical Research Centre at the University of Oxford.
For more information about this new IVF screening technique, read this Philly.com article.
Bryn Mawr Hospital, a member of Main Line Health, is a 319-bed, not-for-profit acute-care teaching hospital dedicated to helping the community stay well ahead on the path to lifelong health. Bryn Mawr Hospital has been named as one of the top six hospitals in the Philadelphia metro area and top 12 in the state of Pennsylvania by U.S. News & World Report’s Best Hospitals 2016–2017, and is ranked as high-performing in the specialties of orthopedics and urology. U.S. News & World Report also ranked Bryn Mawr Hospital as high performing in the following Common Core specialty areas: abdominal aortic aneurysm repair, COPD, colon cancer surgery, congestive heart failure, hip replacement, knee replacement and lung cancer surgery. Bryn Mawr Hospital has earned Magnet® designation for the third time for its superior nursing staff. Bryn Mawr Hospital’s Neuro-Cardiac Intensive Care Unit (NCICU) has also received the 2015–2018 American Association of Critical-Care Nurses (AACN) Silver-level Beacon Award for Excellence for the second time. The National Institutes of Health Commission on Cancer has accredited our Cancer Center and our Comprehensive Breast Center has been accredited by The Joint Commission and the National Accreditation Program for Breast Centers. Bryn Mawr Hospital’s Bariatric Program has been accredited by the American Society for Metabolic and Bariatric Surgery. The hospital offers a full range of services, including cancer care, orthopedic care, cardiovascular care, behavioral health, maternity care, bariatric surgery, neurovascular and a Level III Neonatal Intensive Care Unit, all aided by a dedicated team of health care professionals and innovative technology such as the Intuitive Surgical System's DaVinci Robot and Navio Robotic Arm Orthopedic System. Through Bryn Mawr Hospital’s collaboration with the Jefferson Hospital for Neuroscience, the university-affiliated Neurovascular Center offers rapid access to advanced diagnostics and treatment options for stroke care. Bryn Mawr Hospital has also collaborated with Nemours/Alfred I. duPont Hospital for Children to include round-the-clock pediatric care for the pediatric inpatient unit and in the pediatric emergency department with additional board-certified, fellowship trained pediatric emergency medicine physicians.
Mary Kate Coghlan
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