If your doctor still cannot find the primary site of the cancer after doing tests you may be officially diagnosed with carcinoma of unknown primary origin (CUP). If this happens, a pathologist classifies the cancer as one of these 3 types.
Squamous cell carcinoma
Poorly differentiated malignant neoplasm
You may need some of these additional exams.
Underarm lymph node evaluation
Groin lymph node evaluation
Pelvic organ evaluation
Chest or abdomen evaluation
Evaluation of other locations
Test for melanoma of unknown primary origin in your neck, underarms, or groin lymph nodes
Doctors will repeat a careful physical exam and maybe some of the tests. They will have a second pathologist look at the biopsy samples. Sometimes, as time passes, a small hidden primary tumor may grow enough to be found. This may help the doctors reclassify the CUP.
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