Histidine

Other Name(s):

a-amino-b-[4-imidazole]-propionic acid

Claims:

Histidine is reported to help treat allergies, ulcers, rheumatoid arthritis, and anemia. It is also considered beneficial in improving sexual function and protecting against damage caused by ionizing radiation (e.g., x-rays).

Recommended Intake:

Amino acids (AAs) are available as individual AAs or in proprietary AA combinations, as well as part of multivitamin formulas, proteins, and food supplements. The forms include tablets, fluids, and powders. However, adequate protein in the diet should provide a sufficient source of all amino acids.

There are no conditions that increase the requirements for histidine.

Side Effects and Toxicity:

The use of a single amino acid supplement may lead to negative nitrogen balance, decreasing the metabolic efficiency and increasing the workload of the kidneys. In children, taking single amino acid supplements may also harmfully affect growth parameters.

Excess histidine may cause psychological disorders. Generally, single amino acid supplements are not recommended for people who eat an adequate or even less than adequate amount of protein.

Always avoid taking individual amino acids in high doses for prolonged periods of time.

Women who are pregnant or breast-feeding should not use histidine supplements.

Chemistry:

L-histidine has a molecular formula of C6H9N3O2 and a molecular weight of 155.2.

Web Sites with Additional Information

Click here for a list of reputable Web sites with general information on nutrition.

References:

  1. Weast RC, Astle MJ, Beyer WH, eds. Handbook of Chemistry and Physics. 65th ed. Boca Raton, FL: CRC Press, Inc.; 1984.

  2. Lide DR, Frederikse HPR, eds. Handbook of Chemistry and Physics. 75th ed. Boca Raton, FL: CRC Press, Inc.; 1994.

  3. Murray RK, Granner DK, Mayes PA, Rodwell VW. Harper's Biochemistry. 25th ed. Stamford, CT: Appleton & Lange; 2000.

  4. Meisenberg G, Simmons WH. Principles of Medical Biochemistry. Mosby Pub. Co.; 1998.

  5. Styer L. Biochemistry. 4th ed. W.H. Freeman & Co.; 1995.

  6. Montgomery R, Conway TW, Spector AA, Chappell D. Biochemistry: A Case-Oriented Approach. 6th ed. Mosby Pub. Co.; 1996.

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