Albert S DeNittis , M.D.

GENERAL

Specialty:	Radiation Oncology (Board Certified in 2000) - Accepting New Patients

Age: 47      Gender: M

Medical School:
Robert Wood Johnson

Residency:
University of Pennsylvania Medical School

Affiliations:

• Bryn Mawr Hospital - On staff since 2002
• Lankenau Medical Center - On staff since 2002
• Paoli Hospital - On staff since 2002

Academic Titles:
Clinical Associate Professor - Lankenau Institute for Medical Research

Clinical/Dept Titles:
Chief, Radiation Oncology, Lankenau Hospital
Attending Physician

---

PRACTICE

Practice Name:
Main Line Radiation Oncology

Location:

Lankenau Radiation Oncology 100 East Lancaster Avenue Wynnewood, PA  19096 TEL: 484.476.2433 FAX: 484.476.3595

Access Information:  Public Transportation,Handicap Access Hours: Weekdays

Areas of Clinical Interest
- ASTRO NIH Government Relations Committee
- Chairman, CCOP Membership Evaluation Committee--RTOG
- Principle investigator for the Radiation Therapy Oncology Group (RTOG) for Main Line Health
- Co-Principle Investigator of Main Line Health Clinical Cancer Oncology Program (CCOP)
- Member CCOP Steering/Concept Review Committee - RTOG
Co-Principle Investigator of Main LIne Health CCOP

---

PUBLICATIONS & CITATIONS

Academic Title

Clinical Associate Professor - Lankenau Institute for Medical Research

Recent Clinical Studies Published

Dr. DeNittis has an extensive bibliography of publications and presentations and 5 book chapters, including a chapter in Principles and Practice of Radiation Oncology 5th edition (Lippincott Williams & Wilkins, 2008). Listed below are a few of his publications.

Articles

DeNittis AS, Stambaugh M., Looby C., Ameloblastic fibrosarcoma of the maxilla; Report of a case, J Oral Maxill Surg. Vol 56:672-675 May 1998.

Stambaugh M, DeNittis AS, Wallner PE, Heymann W, Complete remission of refractory dyshidrotic eczema with the use of radiation therapy. Cutis April. 2000.

DeNittis, AS, Stambaugh MD, Lang P, Wallner, PE, Dillman RO, Order SE;Preliminary report, complete remission of nonresectable pancreatic cancer following infusional colloidal brachytherapy, external beam radiation therapy and 5-flurouracil. Am J Clin Oncol. 22(4): 355-360, 1999.

Stambaugh MD, DeNittis AS; Out of field recurrence of an ameloblastic sarcoma of the maxilla. J Oral Maxill Surg., Vol 56:1364, Nov. 1998.

Li, P., Zhuang, H., Mozley, P.D., DeNittis, A.S., Yeh, D., Machtay, M., Smith, R., Alavi, A., Evaluation of recurrent squamous cell carcinoma of the head and neck with FDG positron emission tomagraphy. Clin Nucl Med, Feb., 26(2):131-135, 2001.

Court WS, Order SE, Johnson E., DeNittis AS,. Principato R, Lang P, Martz Zeiger LS: Remission and survival following monthly intra-arterial cisplatin in nonresectable hepatoma. Cancer Investigation 20, 613-615, 2002.

DeNittis AS, Machtay M, Rosenthal DI, Sanfilippo NJ, Lee JH, Goldfeder S, Chalain AA, Weinstein GS, Weber RS; Advanced resectable oropharyngeal carcinoma treated with surgery and postoperative radiothetherapy: Outcome and quality of life assessment. American J of Otolaryngology. Sept. 22(5): 329-335, 2001.

Sanfilippo NJ , Hai RA, DeNittis AS, Ginsberg GG, Kochman ML, Friedberg JS, Hahn SM; Toxicity of Photodynamic therapy after combined external beam radiotherapy and intraluminal brachytherapy for carcinoma of the upper aerodigestive tract. Lasers in Surgery and Medicine: 28:278-281, April 2001.

DeNittis AS, Liu L, Rosenthal DI, Machtay M; Nasopharyngeall carcinoma treated with external radiotherapy (XRT), brachytherapy, and concurrent and adjuvant chemotherapy. Am J Clin Oncol 25(1): 93-95, 2002.

Metz JM, Jones H, DeNittis AS, Hahn S, Female cancer patients frequently use unconventional medical therapies. Med Dosim Fall 26(3):255-9, 2001.

Smith RP, Devine P, Jones H, DeNittis AS, Whittington R, Metz JM, Internet usage by cancer patients undergoing radiation therapy. Journal of Urology 62(2): 273-7, 2003.

Metz JM, Devine P, DeNittis AS, Jones H, Hampshire M, Goldwein J, Whittington R, A multiinstitutional study of internet utilization by radiation oncology patients. Int J of Rad Oncol Biol Phys 56(4):1201, 2003.

Vapiwala N, Mick R, Hampshire M, Metz J, DeNittis AS,  Patient initiation of complementary and alternative medical therapies (CAM). The Cancer Journal, 12(6): 467, 2006.

Marks J, Valsdottir EB, DeNittis AS, Yarandi SS, Newman DA, Nweze I, Marks G, Mohiuddin M. Transanal Endoscopic Microsurgery (TEM) for Treatment of Rectal Cancer: Comparison of wound complication rates with and without neoadjuvant radiation therapy. Surgical Endoscpoy 23:1080-1087, 2009.

Machtay M, Werner-Wasik M, DeNittis AS, Axelrod, Gilman P, Meyer T, Lavarino, Treat J, Curran W, Pilot Study of Carboplatin/Radiotherpy plus Dose Dense Pemetrexed for locally advanced non-small cell lung carcinoma.  Submitted to AJCO 2010. 

Troicki F, Pappas A, Noone R, DeNittis A, Radiation Therapy of recurrent anal squamous cell carcinoma in situ: a case report. J of Medical Case Reports 4:76 2010.

Ward K, Li J, Zhang D, Dayanandam E, DeNittis AS, Prendergast G, Ayene I. Bioactive probe for the mechanisms and implications of the loss of cellular control of thiol redox hemostasis during glucose deprivation. Submitted to The Journal of Biological Chemistry. June 2010.

Abstracts and Presentations

Koprowski, C., Chen Y., Barravecchio A., DeNittis A., Trabold L., Krish E., Prostate implants: A peripheral loading alogorithem and reduced complications. 7th International Prostate Cancer Update Beaver Creek, Colorado, January 22-26, 1997.

Order, S.E., Johnson E., DeNittis A.S., LaCouture T., Lang P., Azure M.T., Principato R., Goldstein D., Zeiger L., Wallner P., Remission and survival following monthly intra-arterial cisplatin in non-resectable hepatoma. Programs/Proceedings of the American Society of Clinical Oncology Annual Meeting Los Angeles, CA May 16-19, 1998.

DeNittis, A.S., Stambaugh, M.D., Lang, P., Wallner, P.E., Dillman, R.O., Order, S.E., Preliminary report: Complete remission of nonresectable pancreas cancer Following Infusional colloidal 32P brachytherapy, external radiation therapy and 5-fU. Presented in ASTRO Phoenix, Arizona, October 25-29, 1998.

DeNittis, A.S., Machtay, M., Lee, J.H., Chalian, A.A., Weinstein, G.S., Weber, R.S., Aviles, V. M., Rosenthal, D.I., Locally advanced Resectable Oropharyngeal Carcinoma: High Local- Regional Control but a High Rate of Distant Metastases with Surgery and Postoperative Radiotherapy. Programs/Proceedings of the American Society of Clinical Oncology Annual Meeting, Atlanta, Georgia. May 1999.

Kollmeier, M., DeNittis, A.S., Rosenthal, D.I., Machtay, M., Extended field simultaneous radiation therapy for synchronous head & neck and esophageal carcinomas. Programs/Proceedings American Society of Clinical Oncology Annual Meeting, Atlanta, Georgia. May, 1999.

DeNittis, A.S., Metastatic Ewing’s sarcoma. Presented at Children’s Hospital of Philadelphia, Philadelphia, Pa April, 29, 1999.

Court W., Order, S., Siegel J., Cayea, P., Kaplan, D., Stillwagon, G., Dillman, R., DeNittis A., Interim Report of a phase II study integrating infusional colloidal 32P brachytherapy with chemoradiation in nonresectable adenocarcinoma of the pancreas. Programs/ Proceedings American Society of Clinical Oncology Annual Meeting, New Orleans Louisianna May 2000.

DeNittis AS, Liu L, Rosenthal DI, Machtay M, Nasopharyngeal carcinoma treated with external radiotherapy (XRT), brachytherapy, and concurrent and adjuvant chemotherapy. 5th International conference on Head and Neck Cancer, San Francisco, Calif., July, 2000.

Metz JM, Jones H, DeNittis AS, Hahn S, Female cancer patients frequently use unconventional medical therapies. Key Note Address, Presented in part at the 18th annual meeting of the Society of Gynecologic Nurse Oncologists, San Diego, California, January 19-23, 2001.

Metz JM, Davine P, DeNittis A, Stambaugh M, Jones H, Goldwein J, Whittington R, Utilization of the internet by oncology patients to obtain cancer related information. Programs/Proceedings American Society of Clinical Oncology Annual Meeting, San Francisco, California, May 2001.

Jones H, DeNittis AS, Hahn S, Metz JM, Disclosure patterns for unconventional medical therapy use in breast cancer patients: Standard history vs. directed questioning. Programs/Proceedings American Society of Clinical Oncology Annual Meeting, San Francisco, California, May 2001.

Metz JM, Devine P, DeNittis AS, Stambaugh MD, Jones H, Goldwein J, Whittington R, Internet utilization by radiation oncology patients. Presented in ASTRO, Abstr. 179, San Francisco, California, November 4, 2001.

Metz JM, Jones HA, Devine P, DeNittis A, Complimentary Medicine (CM) use by cancer patients during conventional cancer treatment: A multi-institutional study. Presented at the 14th International Symposium for Supportive Care in Cancer, Boston, Massachusetts, June 23-26, 2002.

Vapiwala N, DeNittis A, Mick R, Hampshire M, Metz JM, Patient initiation of complementary and alternative medical therapies (CAM) during conventional lung cancer treatment. 11th World Conference on Lung Cancer, Barcelona, Spain, July 2005.

Vapiwala N, Mick R, DeNittis A, Hampshire M, Metz JM, Initiation of complimentary and alternative medical therapies (CAM) by cancer patients during radiation therapy (RT). Presented at ASTRO Abs. Denver, Colorado, October 2005.

Marks JH, Kosinski LA, DeNittis AS, Heinsch D, Marks GJ, Radical proctectomy for rectal cancer following neoadjuvant therapy: Laproscopic vs open resection.  Poster presentation at the American Society Colorectal Surgeons (ASCRS), Washington State Trade and Convention Center, Seattle, Washington, 2006.

Marks JH, Kosinski LA, DeNittis AS, Heinsch D, Marks GJ, Radical proctectomy for rectal cancer following neoadjuvant therapy: Laproscopic vs open resection.  Podium presentation at the Northern  Society of Colorectal Surgeons (NESCRS), Rhode Island, 2006.

DeNittis AS, Marks J, Marks G, Gilman PG, Anderson A, Mohiuddin M, Dose escalation with organ sparing using conformal avoidance intensity modulated radiation therapy for rectal cancer: a dosimetric evaluation. Presented at ASCO GI symposium Orlando, FL. 2007. 

Hunt D, Kosinski L, Mohiuddin M, DeNittis A, Marks G, Marks J,  Transanal endoscopic microsurgery (TEM) for T2 rectal cancer following neoadjuvant radiation.  Presented at the American Society Colorectal Surgeons (ASCRS), St Loius, MO, June 2-7, 2007.

Ntambi J, DeNittis AS, Hagg M, Ali Z, Obrien T, Ornithine Decarboxylase Genotype May Predict Prostate Cancer Risk.  Presented at ASTRO Los Angeles, Ca. 2007.

DeNittis AS, Katz J, Anderson A, Carp N, Gilman P, Weiss M,  Seroma formation during mammosite Brachytherapy can influence prescribed treatment doses.  Presented at ACRO, Miami, Fl  Feb 21, 2008.

DeNittis AS, Ntambi J, Hagg M, Dasgupta A, O’brien T,  Prediction of prostate cancer risk in the Ornithine Decarboxylase genotype. Presented at ASCO GU San Francisco, Ca Feb, 14-16, 2008.

Valsdottir E, Marks J, Yarandi S, Newman D, Mohiuddin M, DeNittis AS, Marks G, Transanal endoscopic microsurgery (TEM) Treatment of rectal cancer: A comparison of outcomes with and without neoadjuvant radiation therapy.  Presented at Society of American Gastrointestinal Endoscopic Surgeons (SAGES) Philadelphia, Pa April 2008.

Valsdottir EB, Newman DA, Yarandi SS, Marks JH, Marks G, DeNittis AS, Number of lymph nodes can not be used as a surrogate for adequacy of resection after neoadjuvant therapy for rectal cancer. Presented at ASCRS 2008.

Machtay M, Werner-Wasik M, DeNittis AS, Axelrod R, Gilman P, Meyer T, Lavarino, Treat J, Curran W, Pilot Study of Carboplatin/Radiotherpy plus Dose Dense Pemetrexed for locally advanced non-small cell lung carcinoma.  Presented at ASCO, Chicago 2008. 

DeNittis AS, Thompson A, Marks G, Valsdottir E, Zeger EL, Marks J. Identifying Rectal Shift Using Cone Beam Computed Tomography During Pre-operative Intensity Modulated Radiation Therapy. Presented at ASTRO, Boston, Sept. 2008. 

DeNittis AS, Li J, Zhang D, Dayanandam E, AyeneI. Radiation Sensitization of Lung Tumor by a Novel Disulfide that Targets Glucose Deprived Cells. Presented at ASTRO, Chicago, Nov 2009.

Shen X, Werner-Wasik M, DeNittis AS, Axelrod R, Gilman P, Meyer T,  Treat J, Curran W, Machtay M. A Final Report of a Pilot Study of Carboplatin/Radiotherpy plus Dose Dense Pemetrexed for locally advanced non-small cell lung carcinoma.  Presented at ASTRO, Chicago, Nov. 2009.

Ward K, Li J, Zhang D, Dayanandam E, DeNittis AS, Prendergast G, Ayene I. HEDS Selectively Radiosensitizes Human Cancer CElls in Glucose-Deprived Environments via Inhibition of Ku Protein Function.Presented at AACR annual meeting, Washington D.C., April 17,2010.

DeNittis AS, Troiki F, Zeger EL, Marks G, Valsdottir J, Marks J. A Report on the Feasibility and Toxicity of Pre-operative Intensity Modulated Radiation Therapy (IMRT) and Chemotherapy Followed by Surgery for Patients with Rectal Cancer. Presented at American Radium Society, CAncun, MExico, MAy 2010.

DeNittis AS, Troiki F, Zeger EL, Marks G, Marks J.Treatment of Rectal Cancer with Pre-operative Intensity Modulated Radiation Therapy (IMRT) Combined with Chemotherapy: Updates 3 Year Results. Accepted ASTRO, San Diego, October 2010.

Books

Barrett’s Esophagus; DeNittis, A.S., Coia, L.R., Chapter on “Radiotherapy in the treatment of adenocarcinoma of the esophagus” pg 367-376, Editor: Tilanus and Atwood, Kluwer Publishers, 2001.

Principles and Practice of Radiation Oncology, 4th edition; Chapter on “Esophageal Cancer,” Editor: Brady and Perez, 2003.

Principles and Practice of Radiation Oncology Updates; Chapter on “Esophageal Cancer”, Editor: Brady and Perez 3 (2): 1-12, 2002.

Principles and Practice of Radiation Oncology Updates; Chapter on “Current Trends in Brain Metastases,” Editor: Brady and Perez, 2004.

Principles and Practice of Radiation Oncology 5th edition, Chapter 50 on “Esophageal cancer”, Co author with Christopher Willet Editor: Brady and Halperin 2008.

Encyclopedia of Radiation Oncology, Chapter on Esophageal Cancer, Editor: Brady & Yaeger 2010.

Recent Honors, Awards, Citations

• Howard H. Wong Fellowship in Radiation Oncology
• Membership Who's Who in Medicine and Healthcare
• Fellowship to the Philadelphia College of Physicians
• Membership Who’s Who in the World
• Membership Who’s Who in America
• Membership Who’s Who in Executives & Professionals
• Main Line Top Doc, 2006
• Main Line Top Doc, 2007

Community/Team Clinical Affiliations

• Cancer Survivors Day
• Man to Man support group through the American Cancer Society

Current Memberships and Activities

• American Medical Association
• American Roentgen Ray Society
• American Society for Therapeutic Radiology and Oncology
• American College of Radiology
• Radiological Society of North America
• American College of Radiation Oncology
• American Society of Clinical Oncology

Membership on the medical staff of any of our hospitals does not constitute an employment or agency relationship.