Cardiac Safety Assessment

The Cardiovascular Research Group (CRG) at LIMR, led by cardiologist Gan-Xin Yan, MD, PhD, provides drug development companies worldwide with a complete range of cardiac safety assessment services. The CRG offers an integrated portfolio of cardiac safety assays from the cellular level to the whole organ. These assays include:

  • Wedge Preparation Assay
  • hERG Potassium Current Analysis
  • INa and ICa Screening
  • Human Cardiomyocyte Ion Channel Assay
  • Action Potential Assay

For a full description of services, download LIMR Cardiovascular Research Group - Cardiac Safety Assessment Services.

The unique ventricular wedge preparation first developed by Dr. Yan has been adopted by many pharmaceutical and biotech companies internationally for cardiac safety assessment. This wedge preparation possesses many advantages over traditional methods to study electrical signals traveling within the heart. Three separate floating microelectrodes are used to record the signals in the outer, mid, and inner regions of the heart. The experimental findings based on the ventricular wedge model have led to several fundamental changes in our thinking as to the origin and maintenance of normal as well as abnormal heart rhythms.

Please contact Dr. Yan for assessment pricing information.

Contact Info

Gan-Xin Yan, MD, PhD
Director
LIMR Cardiovascular
Research Group

LIMR Suite R230
100 East Lancaster Avenue
Wynnewood, PA 19096

484-476-2687 (Office)
484-476-2688 (Lab)
Yan@limr.org

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