Center for Clinical Cancer Research

The Center for Clinical Cancer Research (CCCR) promotes and supports all cancer research across Main Line Health (MLH). The CCCR, led by Director Paul Gilman, MD, System Chief, Division of Hematology/Oncology, LMC, oversees both NCI and non-NCI sponsored clinical and non-clinical trials within LIMR. These include novel trials of experimental therapeutics in oncology, drug development in partnership with pharmaceutical companies, and investigator-initiated trials, which relate to methods, tests and drugs developed here at LIMR. George Prendergast, PhD, Professor, President and CEO of LIMR, is a co-director with Dr. Gilman of the LIMR Program in Cancer Research. The synergy between LIMR’s laboratory programs and the clinical research activities serves as a translational conduit for the movement of laboratory findings into clinical investigations.

NCI Community Oncology Research ProgramMain Line Health recently became a National Cancer Institute (NCI) Community Oncology Research Program (NCORP), one of only 34 in the United States. The NCORP provides patients with access to NCI sponsored cancer clinical trials studying screening, prevention, and symptom management for the oncology patient. The Main Line Health NCORP is currently led by principal investigator Albert DeNittis, MD. The many advantages of the NCI-sponsored consortium between Bryn Mawr Hospital, Lankenau Medical Center, Paoli Hospital and Riddle Hospital to the MLH community include having access to state-of-the-art clinical trials and new cancer treatments before they become available to the general public, and allowing patients to be more active in their healthcare.

Cancer Clinical Trials at Main Line Health

Services provided by the CCCR in conjunction with the Clinical Research Center (CRC)

  • Feasibility review
  • Funding and budgeting review
  • Communication with sponsor
  • Guidance for regulatory/IRB submission
  • Organizing initial site visits and ongoing audit visits
  • Data management guidance
  • Research coordinators
  • Marketing
  • Contract review

Additional services available for investigator-initiated trials

  • Protocol development
  • Statistical design and data analysis
  • Assistance with informed consent form preparation
  • Case report form design
  • Editorial assistance for manuscript preparation

Clinical Trial Initiation Forms

CCCR Staff

Paul Gilman, MD – CCCR Director; Co-Director, LIMR Program in Cancer Research
George Prendergast, PhD – Co-Director, LIMR Program in Cancer Research
Gerald Messerschmidt, MD – Director, Clinical Research Center
Albert DeNittis, MD – NCORP Principal Investigator
Diana Ewen, MPH, CCRP - NCORP Administrator

For more information or questions regarding the Center for Clinical Cancer Research or the NCI Community Oncology Research program, please contact Diana Ewen, 484.476.2649.

Contact Info

Diana Ewen, MPH, CCRP
NCORP Administrator
Cancer Clinical Trials Program
LIMR Center for
Clinical Cancer Research


Main Line Health