Main Line Health Laboratories offers two different tests that measure
the same molecule in serum—C-Reactive Protein (CRP) and high-sensitivity
C-Reactive Protein (hsCRP). These tests have very different clinical
indications (ICD-9 codes), methods of reporting and interpretation, CPT
codes, and reimbursement rates. Please be sure to choose the correct
test that is desired:
C-Reactive Protein (CPT code 86140) has been used for decades as
a measure of inflammation (acute phase reactant), somewhat
analogous to Erythrocyte Sedimentation Rate. Results are
presented with a reference (normal) range; abnormal values are
increased out of the normal range. Please order as “CRP”. The
results for this test have been placed in the general chemistry
section in SmartChart.
High sensitivity C-Reactive Protein (CPT code 86141) is a test
developed in the last few years as a measure of cardiovascular
risk. As the name implies, hsCRP is more sensitive than the
older CRP test, based on the finding that even “normal” levels
of C-Reactive Protein may indicate increased risk of
cardiovascular events if the levels are at the higher end of the
normal range, presumably reflecting low-level inflammation that
contributes to progression of atherosclerosis. Results for hsCRP
are grouped into thirds (tertiles) within the normal range, with
the highest tertile indicating the most risk. Please order as
“hsCRP”. The results for this test have been placed in the
cardiac marker section in SmartChart.
Please note that if a test is ordered as “CRP”, the older, less
sensitive test for inflammation will be reported that is not useful as a
cardiovascular risk marker.
If you have further questions, please feel free to contact Albert
Keshgegian, MD PhD, Medical Director, at 484.476.3552. Thank you for
your support of Main Line Health Laboratories.
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