Scientific Publications

The following selected publications represent some important research that has taken place in the laboratories of LIMR over the past few years. To learn more about a specific paper, click on it below.

• The nursing quality partnership: building a health system approach to improving care in community hospitals using principles of the magnet program of excellence. Valentine NM, Murphy D, Deroberts A, Lyman MB. Nurs Adm Q. Oct 2012;36(4):340-52.
• Amino acid catabolism: a pivotal regulator of innate and adaptive immunity. McGaha TL, Huang L, Lemos H, Metz R, Mautino M, Prendergast GC, Mellor AL. Immunol Rev. Sep 2012;249(1):135-57. doi: 10.1111/j.1600-065X.2012.01149.x.
• Association between pulmonary mycobacterium avium complex infection and lung cancer. Lande L, Peterson DD, Gogoi R, Daum G, Stampler K, Kwait R, Yankowski C, Hauler K, Danley J, Sawicki K, Sawicki J. Thorac Oncol. Sep 2012;7(9):1345-51..
• The Food and Drug Administration Decision Not to Approve the 110 mg Dose of Dabigatran: Give Us a Way Out. Kowey PR, Naccarelli GV. Am J Med. Aug 2012;125(8):732. Epub 2012 May 18.
• IDO Is a Nodal Pathogenic Driver of Lung Cancer and Metastasis Development. Smith C, Chang MY, Parker KH, Beury DW, Duhadaway JB, Flick HE, Boulden J, Sutanto-Ward E, Soler AP, Laury-Kleintop LD, Mandik-Nayak L, Metz R, Ostrand-Rosenberg S, Prendergast GC, Muller AJ. Cancer Discov. Aug 2012;2(8):722-35. Epub 2012 Jul 19.
• New Informatics and Automated Infrastructure to Accelerate New Leads Discovery by High Throughput Screening (HTS). Donover PS, Yohn M, Sim M, Wright A, Gowda S, Allee C, Reichman M. Comb Chem High Throughput Screen. Aug 28, 2012 [Epub ahead of print].
• Zinc Supplementation Modifies Tight Junctions and Alters Barrier Function of CACO-2 Human Intestinal Epithelial Layers. Wang X, Valenzano MC, Mercado JM, Zurbach EP, Mullin JM. Dig Dis Sci. Aug 19, 2012 [Epub ahead of print].
• A bioactive probe of the oxidative pentose phosphate cycle: Novel strategy to reverse radioresistance in glucose deprived human colon cancer cells. Li J, Ward KM, Zhang D, Dayanandam E, DeNittis AS, Prendergast GC, Ayene IS. Toxicol In Vitro. Aug 16, 2012 [Epub ahead of print].
• Alcohol does not increase slow wave sleep. Pressman MR. Alcohol Clin Exp Res. Aug 2012;36(8):1474. doi: 10.1111/j.1530-0277.2012.01746.x. Epub 2012.
• Primary pericardial mesothelioma unique case and literature review. Sardar MR, Kuntz C, Patel T, Saeed W, Gnall E, Imaizumi S, Lande L. Tex Heart Inst J. 2012 39(2):261-4.
• Chang MY, Boulden J, Valenzano MC, Soler AP, Muller AJ, Mullin JM, Prendergast GC (2012). Bin1 attenuation suppresses experimental colitis by enforcing intestinal barrier function. Dig Dis Sci. Jul;57(7):1813-21. Epub 2012 Apr 18.
• Pigott E, Mandik-Nayak L (2012). Addition of an indoleamine 2,3,-dioxygenase inhibitor to B cell-depletion therapy blocks autoreactive B cell activation and recurrence of arthritis in K/BxN mice. Arthritis Rheum. Jul;64(7):2169-78. doi: 10.1002/art.34406.
• Farrell C, Morgan M, Tully O, Wolov K, Kearney K, Ngo B, Mercogliano G, Thornton JJ, Valenzano MC, Mullin JM.
• Whellan DJ, Droogan CJ, Fitzpatrick J, Adams S, McCarey M, Andrel J, Mather P, Rubin S, Bonita R, Keith S (2012). Change in Intrathoracic Impedance Measures During Acute Decompensated Heart Failure Admission: Results From the Diagnostic Data for Discharge in Heart Failure Patients (3D-HF) Pilot Study. J Card Fail. Feb;18(2):107-12.
• Schulman EA, Hohler AD (2012). The American Academy of Neurology position statement on abuse and violence. Neurology [epub ahead of print, Jan. 25, 2012].
• Hayes CS, Defeo K, Dang H, Trempus C, Morris R, Gilmour SK (2011). A prolonged and exaggerated wound response with elevated ODC activity mimics early tumor development. Carcinogenesis Sep;32(9):1340-8.
• Stampler KM, Holtz DO, Dunton CJ (2011). Reducing excessive toxicity in ovarian cancer treatment: a personalized approach. Future Oncol. 7(6):789-98.
• Prendergast GC, Chang MY, Mandik-Nayak L, Metz R, Muller AJ (2011). Indoleamine 2,3-dioxygenase as a modifier of pathogenic inflammation in cancer and other inflammation-associated diseases. Curr Med Chem. 18(15):2257-62.
• Wang X, Tully O, Ngo B, Zitin M, Mullin JM. Epithelial tight junctional changes in colorectal cancer tissues (2011). Scientific World Journal 11:826-41.
• Droogan C, Patel C, Yan GX, Kowey PR (2011). Role of antiarrhythmic drugs: frequent implantable cardioverter-defibrillator shocks, risk of proarrhythmia, and new drug therapy. Heart Fail Clin. 7(2):195-205, viii.
• Adekar SP, Segan AT, Chen C, Bermudez R, Elias MD, Selling BH, Kapadnis, BP, Simpson LL, Simon PM, Dessain SK (2011). Enhanced neutralization potency of botulinum neurotoxin antibodies using a red blood cell-targeting fusion protein. PloS One. 6(3):e17491.
• Huang M, Satchell L, Duhadaway JB, Prendergast GC, Laury-Kleintop LD (2011). RhoB links PDGF signaling to cell migration by coordinating activation and localization of Cdc42 and Rac.J Cell Biochem. 112(6):157-84.
• Yan GX, Yuan Z (2011). Inhibition of triggered activities in pulmonary veins: Do statins have a direct and clinically relevant antiarrhythmic effect?J Am Coll Cardiol. 57(8):994-5.
• Kowey PR, Reiffel JA, Ellenbogen KA, Naccarelli GV, Pratt CM (2010). Efficacy and safety of prescription omega-3 fatty acids for the prevention of recurrent symptomatic atrial fibrillation: a randomized controlled trial. JAMA. 304(21):2363-72. Epub 2010 Nov 15.
• Katz JB, Curran AL, Zemba-Palko V, Dabrow MB, Denshaw-Burke MT (2010). Synchronous diagnosis of chronic lymphocytic leukemia and acute myeloid leukemia. J Clin Oncol. 28(35):e726-8. Epub 2010 Sep 13.
• Huang YH, Cozzitorto JA, Richards NG, Eltoukhy AA, Yeo CJ, Langer R, Anderson DG, Brody JR, Sawicki JA (2010). CanScript, an 18-base pair DNA sequence, boosts tumor cell-specific promoter activity: implications for targeted gene therapy.Cancer Biol Ther. 10(9):878-84. Epub 2010 Nov 1.
• Muller AJ, DuHadaway JB, Jaller D, Curtis P, Metz R, Prendergast GC (2010). Immunotherapeutic suppression of indoleamine 2,3-dioxygenase and tumor growth with ethyl pyruvate. Cancer Res. 70(5):1845-53. Epub 2010 Feb 16. 
• Metz R, DuHadaway J, Rust S, Munn DH, Muller AJ, Mautino M, Prendergast GC(2010). Zinc protoporphyrin-IX stimulates tumor immunity by disrupting the immunosuppressive enzyme indoleamine 2,3-dioxygenase. Mol. Cancer Ther. 9(6):1864-71.
• Burns MR, Graminski GF, Weeks RS, Chen Y, O'Brien TG (2009). Lipophilic lysine-spermine conjugates are potent polyamine transport inhibitors for use in combination with a polyamine biosynthesis inhibitor. J Med Chem. 52(7):1983-93.
• Kowey PR, Dorian P, Mitchell LB, Pratt CM, Roy D, Schwartz PJ, Sadowski J, Sobczyk D, Bochenek A, Toft E (2009). Vernakalant hydrochloride for the rapid conversion of atrial fibrillation after cardiac surgery: a randomized, double-blind, placebo-controlled trial.Atrial Arrhythmia Conversion Trial Investigators. Circ Arrhythm Electrophysiol. 2(6):652-9. Epub.
• Liss M, Sreedhar N, Keshgegian AA, Sauter G, Chernick MR, Prendergast GC, Wallon UM (2009). Tissue inhibitor of metalloproteinase-4 (TIMP-4) is elevated in early-stage breast cancers with accelerated progression and poor clinical course. Amer J Pathol 175: 940-946.
• Gerhart J, Pfautz J, Neely C, Elder J, Duprey K, Menko AS, Knudsen K, George-Weinstein M (2009). Noggin producing MyoD+ cells are crucial for eye development. Dev Biol 336: 34-41.
• Connolly SJ, Ezekowitz MD, Yusuf S, Eikelboom J, Oldgren J, Parekh A, Pogue J, Reilly PA, Themeles E, Varrone J, Wang S, Alings M, Xavier D, Zhu J, Diaz R, Lewis BS, Darius H, Diener HC, Joyner CD, Wallentin L (2009). Dabigatran versus Warfarin in Patients with Atrial Fibrillation. N Engl J Med 361: 1139.
• Huang YH, Zugates GT, Peng W, Holtz D, Dunton C, Green JJ, Hossain N, Chernick MR, Padera RF Jr, Langer R, Anderson DG, Sawicki JA (2009). Nanoparticle-delivered suicide gene therapy effectively reduces ovarian tumor burden in mice. Cancer Res. 69: 6184-91.
• Murray LJ, Gabello M, Rudolph DS, Farrell CP, Morgan M, Martin AP, Underwood JC, Valenzano MC, Mullin JM (2009). Transmucosal gastric leak induced by proton pump inhibitors. Dig Dis Sci 54: 1408-17.
• Scott GN, DuHadaway J, Pigott E, Ridge N, Prendergast GC, Muller AJ, Mandik-Nayak L (2009). The immunoregulatory enzyme IDO paradoxically drives B cell-mediated autoimmunity. J Immunol 182: 7509-17.
• Gabello M, Valenzano MC, Barr M, Zurbach P, Mullin JM (2009). Omeprazole Induces Gastric Permeability to Digoxin. Dig Dis Sci, Epub online Jun 10.
• Mullin JM, Skrovanek SM, Valenzano MC (2009). Modification of tight junction structure and permeability by nutritional means. Ann N Y Acad Sci 1165: 99-112.
• Ezekowitz MD, Connolly S, Parekh A, Reilly PA, Varrone J, Wang S, Oldgren J, Themeles E, Wallentin L, Yusuf S (2009). Rationale and design of RE-LY: randomized evaluation of long-term anticoagulant therapy, warfarin, compared with dabigatran. Am Heart J. 157(5): 805-10.
• Huang YH, Bao Y, Peng W, Goldberg M, Love K, Bumcrot DA, Cole G, Langer R, Anderson DG, Sawicki JA (2009). Claudin-3 gene silencing with siRNA suppresses ovarian tumor growth and metastasis. Proc Natl Acad Sci USA 106: 3426-30.
• Levatan CS, Upham LV, Deng S, Laury-Kleintop L, Kery V, Nolan R, Quinlan J, Torres C, El-Hajj RJ (2008). Discovery of a human peptide sequence signaling islet neogenesis. Endocr Pract 14(9): 1075-1083.
• Sawicki JA (2008). Fetal microchimerism and cancer. Cancer Res 68(23): 9567-9569.
• Muller AJ, Sharma MD, Chandler PR, Duhadaway JB, Everhart ME, Johnson BA, Kahler DJ, Pihkala J, Soler AP, Munn DH, Prendergast GC, Mellor AL (2008). Chronic inflammation that facilitates tumor progression creates local immune suppression by inducing indoleamine 2,3 dioxygenase. Proc Natl Acad Sci USA 105(44): 17073-78.
• Lu Z, Kou W, Du B, Wu Y, Zhao S, Brusco OA, Morgan JM, Capuzzi DM (2008). Chinese Coronary Secondary Prevention Study Group. Effect of xuezhikang, an extract from red yeast chinese rice, on coronary events in a chinese population with previous myocardial infarction. Am J Cardiol 101(12): 1689-1693.