Li Zhang, MD

Photo of Li Zhang

Email:  ZhangLi@limr.org

Phone: 484.476.2694

Office: R129-A

Department: Faculty

Association: Resident Faculty

Clinical Department: Cardiology

Other Appointment:Director, Cardiovascular Outcomes Research, Main Line Health

Education:

1977-82 Doctor of Medicine, Xi’an Medical University, Xi’an, China

Current Appointments:

2008 to Present: Director, Cardiovascular Outcomes Research, Main Line Health Heart Center, Lankenau Medical Center

2010 to Present: Associate Professor, Lankenau Institute for Medical Research

Research Interests:

Research Summary

Dr. Li Zhang, a clinical research scientist and Associate Professor of Jefferson Medical College, is specialized in investigating inherited arrhythmias associated with increased risks of sudden death in young otherwise healthy individuals. Li is a principal investigator (PI) of an ongoing project entitled “sudden death prevention-identifying the ECG markers in the early stage of ARVD awarded by American Heart Association Scientist Development Grant (2007-2012)” and a PI for a new study entitled “Lack of Adaptive Left Ventricular Hypertrophy in Athletes with Arrhythmogenic Right Ventricular Dysplasia-Is it a Disease Indicator? awarded by Sharpe-Strumia Research Foundation (2011-2012). She is also a co-investigator in the mutation functional expression studies of ARVD and LQTS sponsored by AHA and NIH (PI, Zhengfeng Zhou, Univ. of Oregon, 2008-2012), respectively.  Dr. Zhang’s primary research goal is to improve the early diagnosis of lethal heart rhythm disorder for prompt medical intervention and sudden death prevention. She is an author/co-author of more than 140 research publications in peer reviewed cardiology journals.  She is also a major contributor in establishing LQTS, ARVD and left ventricular noncompaction registry studies in China.

Dr. Zhang's Google Scholar page

Selected Publications

  1. Zareba W, Moss AJ, Schwartz PJ, Vincent GM, Robinson JL, Priori SG, Benhorin J, Locati EH, Towbin JA, Keating MT, Lehmann MH, Hall WJ, Zhang L: For the International LQTS Registry. Influence of Genotype on the Clinical Course of the Long QT Syndrome. New England Journal of Medicine 1998;339(14):960-965.
  2. Moss AJ, Robinson JL, Gessman L, Gillespie R, Zareba W, Andrews ML, Hall J, Schwartz PJ, Vincent GM, Benhorin J, Locati EH, Towbin JA, Priori SG, Napolitano C, Zhang L, Medina A, Timothy K: Comparison of Clinical and Genetic Variables of Cardiac Events Associated with Loud Noise Versus Swimming Among Subjects with the Long QT Syndrome. American Journal of Cardiology 1999;84:876-879.
  3. Zhang L, Timothy KW, Vincent GM, Lehmann MH, Fox J, Giuli LC, Shen J, Priori SG, Compton SJ, Yanowitz F, Benhorin J, Moss AJ, Schwartz PJ, Robinson JL, Wang Q, Zareba W, Keating MT, Towbin JA, Napolitano C, Medina A: The Spectrum of ST-T Wave Patterns and Repolarization Parameters in Congenital Long QT Syndrome: ECG Findings Identify Genotypes. Circulation. 2000;102:2849-2855.
  4. Kimbrough J, Moss AJ, Zareba W, Robinson JL, Hall WJ, Benhorin J, Locati EH, Medina A, Napolitano C, Priori S, Schwartz PJ, Timothy K, Towbin JA, Vincent GM, Zhang L: Clinical Implications for Affected Parents and Siblings of LQTS Probands. Circulation 2001;104 (5):557-62.
  5. Moss AJ, Zareba W, Kaufman ES, Gartman E, Peterson DR, Benhorin J, Towbin JA, Keating MT, Priori SG, Schwartz PJ, Vincent GM, Robinson JL, Andrews ML, Feng C, Hall WJ, Medina A, Zhang L, Wang Z. Increased Risk of Arrhythmia Events in Long QT Syndrome with Mutations in the Pore Region of the Human Ether-a-go-go Related Gene Potassium Channel. Circulation 2002: 105:7:794-799.
  6. Zareba W, Moss AJ, Locati EH, Lehmann MH, Peterson DR, Hall WJ, Schwartz PJ, Vincent GM, Priori SG, Benhorin J, Towbin JA, Robinson JL, Andrews ML, Napolitano C, Timothy K, Zhang L, Medina A, for the International Long QT Syndrome Registry. Modulating Effects of Age and Gender on the Clinical Course of Long QT Syndrome by Genotype. J Am Coll Cardiol 2003;42:103-109.
  7. Chen S, Zhang L, Bryant RM, Vincent GM, Flippin M, Lee JC, Brown E, Zimmerman F, Rozich R, Szafranski P, Oberti C, SterbaR, Marangi D, Tchou PJ, Chung MK, Wang Q. KCNQ1 mutations in patients with a family history of lethal cardiac arrhythmias and sudden death. Clin Genet 2003;63:273-282.
  8. Zhang L, Vincent GM, Baralle M, Baralle FE, Anson B, Benson DW, Whiting B, Timothy KW, Carlquist J. January CT, Keating MT, Splawski I. An Intronic Mutation Causes Long QT Syndrome. J Am Coll Cardiol 2004;44-1283-91.
  9. Zhang L, Benson DW, Tristani-Firouzi M, Ptacek LJ, Tawil R, Schwartz PJ, George AL, Horie Minoru, Anderlfinger G, Fu YH, Ackerman MJ Vincent GM. ECG Features in Patients with KCNJ2 Mutations: Characteristic T-U Wave patterns Predict Genotype. Circulation 2005;111:2720-2726.
  10. Hobbs JB, Peterson DR, Moss AJ, McNitt S, Zareba W, Goldenberg I, Qi M, Robinson JL, Sauer AJ, Ackerman MJ, Benhorin J, Kaufman ES, Locati EH, Napolitano C, Priori SG, Towbin JA, Vincent GM, Zhang L. Risk of aborted cardiac arrest or sudden cardiac death during adolescence in the long-QT syndrome. JAMA 2006 Sep 13;296(10):1249-54.
  11. Sauer AJ, Moss AJ, McNitt S, Peterson DR, Zareba W, Robinson JL, Qi M, Goldenberg I, Hobbs JB, Ackerman MJ, Benhorin J, Hall WJ, Kaufman ES, Locati EH, Napolitano C, Priori SG, Schwartz PJ, Towbin JA, Vincent GM, Zhang L. Long QT syndrome in adults. J Am Coll Cardiol 2007 Jan 23;49(3):329-37.
  12. Seth R, Moss AJ, McNitt S, Zareba W, Andrews ML, Qi M, Robinson JL, Goldenberg I, Ackerman MJ, Benhorin J, Kaufman ES, Locati EH, Napolitano C, Priori SG, Schwartz PJ, Towbin JA, Vincent GM, Zhang L. Long QT syndrome and pregnancy. J Am Coll Cardiol. 2007 Mar 13;49(10):1092-8.
  13. Gong Q, Zhang L, Vincent GM, Horne BD, Zhou ZF. Nonsense Mutations in hERG Cause a Decrease in Mutant mRNA Transcripts by Nonsense-mediated mRNA Decay in Human Long QT Syndrome. Circulation 2007,116(1):17-24. PMCID: PMC2376840.
  14. Martini B, Sperotto C, Zhang L. Cardiac Incidentaloma: Left Ventricular Non-Compaction in a Kindred With Familial Coronary Artery Disease.  Cardiol J 2007;14:407-410.
  15. Antzelevitch C, Sicouri S, Di Diego JM, Burashnikov A, Viskin S, Shimizu W, Yan GX, Kowey P, Zhang L. Does Tpeak-Tend provide an index of transmural dispersion of repolarization? Heart Rhythm 2007 Aug;4(8):1114-6.
  16. Gong Q,  Zhang L, Moss AJ, Vincent GM,  Ackerman MJ, Robinson JC, Jones MA, Tester DJ, and Zhou  ZF. Cryptic splicing caused by a splice site mutation in hERG leads to a large in-frame insertion in long QT syndrome. Journal of Molecular and Cellular Cardiology  J Mol Cell Cardiol. 2008;44(3):502-9. PMCID: PMC2346779.
  17. Goldenberg I, Moss AJ, Bradley J, Polonsky S, Peterson DR, McNitt S, Zareba W, Andrew ML, Robinson JL, Ackerman MJ, Benhorin J, Kaufman ES, Locati EH, Napolitano C, Priori SG, Qi M, Peter J. Schwartz PJ, Towbin JA, Vincent, Zhang L. LQTS after age 40. Circulation 2008;117(17)2192-201.
  18. Pérez Riera AR, Uchida AH, Schapachnik E, Dubner S, Zhang L, Filho CF, Ferreira C, Ferrara DF, de Luna  AB, Moffa PJ. The history of the left septal fascicular block: chronological considerations of a reality yet to be universally accepted. India Pacing Electrophysiol J 2008;1;8(2):114-28, PMCID: PMC2586670.
  19. Kaufman ES, McNitt S; Moss AJ, Zareba W, Robinson JL, Hall WJ, Ackerman MJ, Benhorin J, Locati ET, Napolitano C, Priori SG, Schwartz PJ, Towbin JA, Vincent GM, Zhang L. Risk of death in the long QT syndrome when a sibling has died Heart Rhythm 2008;5(6):831-6. PMCID: PMC2486317.
  20. Pérez Riera AR, Uchida AH, Schapachnik E, Dubner S, Zhang L, Filho CF, Ferreira C. Early repolarization variant: Epidemiological aspects, mechanism and differential diagnosis. Cardiology J 2008;15(1):4-16.
  21. Goldenberg I, Moss AJ, Peterson DR, McNitt S, Zareba W, Andrew ML, Robinson JL, Locati EH, Ackerman MJ, Benhorin J, Kaufman ES, Napolitano C, Priori SG, Qi M, Peter J. Schwartz PJ, Towbin JA, Vincent, Zhang L. Risk factors for aborted cardiac arrest and sudden cardiac death in children with the congenital long-QT syndrome. Circulation 2008;117(17)2184-91.
  22. Vincent GM, Schwartz, PJ, Denjoy,I, Swan H, Bithell C, Spazzolini C, Crotti L, Piippo K, Lupoglazoff JM, Villain E,  Priori SG, Napolitano C, Zhang L. High Efficacy of Beta-Blockers in Long QT syndrome Type 1: Contribution of non-compliance and QT prolonging drugs in the occurrence of Beta-blocker “failure”. Circulation  2009, 20;119(2):215-21 .
  23. Qiu XL, Liu WL, Hu DY, Zhu TG, Li CL, Li L, Zhang L.  Novel  plakophilin-2 mutations in symptomatic Chinese patients with arrhythmogenic right ventricular dysplasia. Amer J Cardiol 2009,103:1439-1444.
  24. Ma KJ, Li N, Wang HT, Chu JM, Fang PH, Yao Y, Ma J, Hua W, Zhang S, Wang FZ, Zhang L and Pu JL, Clinical study of 39 Chinese patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy. Chinese Medical Journal 2009;122(10):1133-1138
  25. Zhang L, Shaik Z, Dubner S, Perez Riera AR, Schapachnik E, Yan GX, Kowey, PR. Long QT Syndrome. Rev Argent Cardiol 2010:27-46.
  26. Goldenberg I, Horr S, Moss AJ, Lopes CM, Barsheshet A, McNitt S, Zareba W, Andrews ML, Robinson JL, Locati EH, Ackerman MJ, Benhorin J, Kaufman ES, Napolitano C, Platonov PG, Priori SG, Qi M, Schwartz PJ, Shimizu W, Towbin JA, Vincent GM, Wilde AA, Zhang L. Risk for life-threatening cardiac events in patients with genotype-confirmed long-QT syndrome and normal-range corrected QT intervals. J Am Coll Cardiol 2011;57(1):51-9.
  27. Sun Y, Quan XQ, Fromme S, Cox RH, Zhang P, Zhang L, Guo D, Guo J, Patel C, Kowey PR, Yan GX. A novel mutation in the KCNH2 gene associated with short QT syndrome. J Mol Cell Cardiol 2011;50(3):433-41.
  28. Liu JF, Jons C, Moss AJ, McNitt S, Peterson, DR, Qi M, Zareba W, Robinson JL, Barsheshet A, Ackerman, MJ, Benhorin J, Kaufman ES, Locati EH, Carlo Napolitano, C, Priori SG, Schwartz PJ, Towbin J, Vincent GM, Zhang L, Goldenberg I. Risk Factors for Recurrent Syncope and Subsequent Fatal or Near-Fatal Events in Children and Adolescents with Long QT Syndrome. J Am Coll Cardiol 2011 22;57(8):941-50.
  29. Mathias A, Moss AJ, Lopes CM, Barsheshet A, McNitt S, Zareba W, Robinson JL, Locati EH, Ackerman MJ, Benhorin J, Kaufman ES, Platonov PG, Qi M, Shimizu W, Towbin JA, Michael Vincent G, Wilde AA, Zhang L, Goldenberg I. Prognostic implications of mutation-specific QTc standard deviation in congenital long QT syndrome. Heart Rhythm. 2013 May;10(5):720-5. doi: 10.1016/j.hrthm.2013.01.032.
  30. Gao YF, Xue XL, Hu DY, Liu WL; Yuan Y, Sun HM, Li L, Timothy TW, Zhang L, Li CL, Yan GX. Inhibition of Late Sodium Current by Mexiletine: A Novel Pharmotherapeutical Approach in Timothy Syndrome. Circulation-Arrhythmia and Electrophysiology 2013;6:614-622.
  31. Liu WL, Qiu XL, Hu DY, Zhu TG, Wang CL Beer D, Zhang L. From recurrent syncope to sudden cardiac death-clinical characteristics in a Chinese patient carrying a plakophilin-2 gene mutation. Case Reports in Cardiology vol. 2013, Article ID 246891 http://www.hindawi.com/crim/cardiology/2013/246891/.
  32. Khaji A, Zhang L, Kowey PR, Martinez-Lage M, Kocovic D. Mega-Epsilon Waves on 12-Lead ECG— Just Another Case Of Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy? J Electrocardiol 2013 Sep 6. pii: S0022-0736(13)00413-5.
  33. Wang F, Liu JQ, Hong L, Liang L, Graff C, Yang YZ, Christiansen M, Olesen SP, Zhang L, Kanters JK. The Phenotype Characteristics of Type-13 Long QT Syndrome. Heart Rhythm 2013 Oct;10(10):1500-6.
  34. Zhang L, Kowey, PR. Andersen-Tawil Syndrome. Case 92 in Chapter 12. ECG Curiosities. Atlas of Advanced Electrocardiogram Interpretation: [Edited by Baranchuk] REMEDICA, London, UK 2013. www.ecgatlas.com (book chapter).
  35. Zhang L, Liu LW, Kowey PR, Fontaine GH. The Electrocardiographic Manifestations of Arrhythmogenic Right Ventricular Dysplasia. Curr Cardiol Rev. 2014 Aug;10(3):237-45.
 
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