Gan-Xin Yan, MD, PhD

Photo of Gan-Xin Yan

Email:  Yan@limr.org

Phone: 484.476.2687

Office: R230

Department: Faculty

Association: Resident Faculty

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Education

  • M.D. Medicine, Hubei Medical College, Hubei, P.R , China, 1982
  • M.Sc. Physiology, Henan Medical University, Henan, P .R. China, 1986
  • Residency, Physiology, Henan Medical University, Henan, P .R. China, 1986-87
  • Ph.D., Physiology University of Bern, Bern, Switzerland, 1991

Appointments

  • Professor of Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA
  • 2008 to Present: Professor, Lankenau Institute for Medical Research

Research Interests

Lab Personnel

  • Victoria Robinson, Postdoctoral Fellow II
  • Tengxin Lui, Research Laboratory Associate

Research Summary:

Our laboratory focuses on exploring the mechanisms responsible for sudden cardiac death under various clinical conditions, including life-threatening rapid and irregular heart beats, myocardial infarction (“heart attack”), enlarged and weakened heart. These cardiovascular studies, from the organ to a single isolated cardiac cell, have contributed a great deal to our understanding of normal electrophysiology as well as electrical disturbances in heart disease. Recently, the lab has started a new project to inject bone marrow cells into heart for repairing weakened heart muscles.

An animal ventricular wedge preparation which I developed has received a great deal of attention and has been adopted by many universities and pharmaceutical companies worldwide. This wedge preparation possesses many advantages over traditional methods to study electrical signals traveling within the heart. From the wedge preparation, three separate floating microelectrodes are used to record the signals in the outer, mid and inner regions of the heart. The experimental findings based on the ventricular wedge model have led to several fundamental changes in our thinking as to the origin and maintenance of normal as well as abnormal heart rhythms. For more information, please visit Cardiac Safety Assessment Services.

Dr. Yan's Google Scholar page

Selected Publications:

  1. Lu HR, Yan GX, Gallacher DJ. A new biomarker--index of cardiac electrophysiological balance (iCEB)--plays an important role in drug-induced cardiac arrhythmias: beyond QT-prolongation and Torsades de Pointes (TdPs). J Pharmacol Toxicol Methods. 68(2):250-9, 2013.

  2. hu J, Li Y, Ju R, Yan GX. Two Types of T Wave Alternans in Long-QT Syndrome. J Cardiovasc Electrophysiol. 25(8):910-2, 2014.

  3. Guo D, Yu M, Liu Q, Cox RH, Liu T, Yan GX. Ventricular hypertrophy amplifies transmural dispersion of repolarization by preferentially increasing the late sodium current in endocardium. J Electrocardiol. 47(5):642-8, 2014.

  4. Badri M, Bradley J, Ju R, Yan GX. Cardiac Metastasis Causing Right Bundle Branch Block and Recurrent Septal Ventricular Tachycardia. J Cardiovasc Electrophysiol.  25(7):793-4, 2014

 
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