LIMR Chemical Genomics Center (LCGC)

Orthogonal-Pooled Screening (OPS)

Intelligent compound-pooling guarantees successful outcomes while reducing cost, time and overhead by 80%.

• Provides medicinal chemists just-in-time new scaffolds for key decision making on lead drug and backup-candidate development.
• Screens five targets for the equivalent cost and effort of a single screen.

Ultra-HTS for Synergy

New paradigm in combinatorial drug discovery.

• Elegant method to identify unexpected (i.e., patentable) synergistic drug combinations.
• Applicable to branded, generic and OTC drugs. Suitable for pharmaceutical repositioning, ChemAg applications and nutraceutical R&D.
• "Drug combination boxes" are now available representing the pharmacological compendium of FDA-approved drugs and nutraceuticals.
• 15:1 compression = 1500% improved efficiency
• Special combination boxes for "conditioned HTS" (e.g., synthetic-lethal).
• Unprecedented potential for identifying binary and ternary combinations.

Automated Compound Repository

State-of-the-art, automated storage and retrieval system preserves quality of chemical assets and supports focused drug discovery and pharmacophore modeling.

• Innovative robotic repository (issued two U.S. patents) stores and distributes chemical assets — with no freeze-thaw cycling.
• Preserves sample quality indefinitely; optimal for compound management or DNA storage and other biorepository applications.
• Storage and retrieval capacity for 10 million samples with high-throughput pick rates of up to 10,000/day.
• Available at no additional cost to our OPS users, providing access to our unique compound collections and services.

Compound Libraries

The Core FMC Collection of 104,000 drug-like small molecules was the proprietary R&D asset of a top-tier Chem-Ag company.

• First-ever proprietary ChemAg library made available to scientists for pharmaceutical R&D.
• Contains thousands of unique scaffolds not available anywhere else.
• Analysis by HPLC/MS demonstrates the collection meets a high QC/QA benchmark.
• Computationally filtered library considered "drug-like" by "Lipinski Rules" and many other drug-filtering algorithms. An example of the cheminformatic profiling is shown.

LCGC HTS libraries also include these other sets:

• ChemBridge — 100,000 compounds assembled from the 50,000-member DIVERSet™-EXP library, plus the 50,000-compound DIVERSet™-CL library
• Life Chemicals Inc — 50,000 compounds selected to complement overall diversity.
• MicroSource Pharmakon — 1,760 combines the 1,360 drugs in its U.S. drug collection with the 400 drugs from the international drug collection.
• MicroSource Spectrum — ~1,000 bioactive compounds and natural product analogs.
• NCI-Approved Oncology Set — 166 of the most current FDA-approved anticancer drugs.
• Nutraceuticals — ~150 individual neat powders acquired from Sigma, Cayman and other vendors.
• Misc. — ~8,000 compounds acquired from other commercial vendors, primarily ChemDiv and TimTec.